In the 1920s, State Highway 152 followed today's Route 45.

The modern Route 152 was commissioned in 1932; few or no changes since then. However, the state did intend to decommission the route per the 1961 reclassification act, and this remained in arbitration until 1969. The state ended up keeping Route 152 in the state highway system.

Route 152 Ends (Photos; Doug Kerr at state-ends.com)